I have been running BigSur from the first beta up to the current pre-release beta version 11.0.1. WeatherCat has been running just fine without any obvious problems through each iteration. No problem with USB data logger and SiLabsUSBDriver 5.3.5 (2/25/2020), either.
Granted, I’ve not tested every conceivable feature of WeatherCat; however, when I installed BigSur, WeaatherCat picked up right where Catalina left off with no intervention.
For those skeptical of new software, please note that the computer feeding
my web site, WU, CWOP, and additional services is an old MacMini running High Sierra.

David